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Anti-Acetyllysine Mouse mAb
Catalog Number: PTM-101
$ 330

Clone Number: Kac-01

Host: Mouse Clonality: Monoclonal

Applications： WB IHC-P

Reactivity: All

Synonyms: Kac

Product Size
100 μl
Quantity

Shipping: Ambient temperature

Order online or send purchase order to info@ptmbio.com

FAQ Technical Support Protocols

General Information
Isotype IgG
Conjugate Unconjugated
Synonyms Kac
UniProt ID

/

Immunogen Acetylated lysine peptides
MW (kDa) Multiple
Specificity Anti-Acetyllysine Mouse mAb detects proteins with acetylated lysine residues. This pan antibody recognizes acetylated lysine independent of its surrounding sequences.
Product Usage Information
Applications Dilution Recommended Species
WB 1:1000 All
IHC-P 1:500 - 1:2000 Human, Mouse
Properties
Purity Protein G and immunogen affinity purified
Constituents PBS, Glycerol, BSA
Storage Store at -20°C. Avoid freeze/thaw cycles.
Stability Stable for 12 months from date of receipt/reconstitution.
Target Information

Background

The reversible lysine acetylation of histones and non-histone proteins is a crucial post-translational modification that regulates diverse cellular processes, including chromatin dynamics, gene expression, cell cycle progression, apoptosis, differentiation, DNA replication, DNA repair, nuclear import, and neuronal repression. More than 20 acetyltransferases and 18 histone deacetylases (HDACs) have been identified, but the mechanisms governing substrate selection and site specificity of these enzymes remain unclear. Dysregulation of protein acetylation has been implicated in the development of cancers and other diseases, and HDACs have become likely targets for anti-cancer drugs.

Cellular location

/

Images
Dot Blot

Protein amount: 4 ng, 20 ng, 100 ng, 500 ng
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Mouse IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
The list of proteins used in the experiment is provided below.
Lane 1: Acetylated BSA. Lane 2: Propionylated BSA.
Lane 3: Butyrylated BSA. Lane 4: Unmodified BSA.
WB

Lysates: HeLa cells
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: (A) PTM-101+BSA, (B) PTM-101+acetylated BSA, 2 hours at room temperature
Secondary Ab: Goat Anti-Mouse IgG H&L pAb (HRP Conjugate)
Exposure time: 60 seconds
Predicted band size: Multiple
Observed band size: Multiple

Lysates: (-) HeLa cells; (+) HeLa cells treated with 30 mM sodium butyrate for 4 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Mouse IgG H&L pAb (HRP Conjugate)
Exposure time: 60+ seconds
Predicted band size: Multiple
Observed band size: Multiple

Lysates: (-) HepG2 cells; (+) HepG2 cells treated with 5 mM sodium butyrate for 24 hours
Protein loading amount: 20 μg
Blocking buffer: 5% NFDM/TBST
Primary Ab dilution: 1:1000
Primary Ab incubation: 2 hours at room temperature
Secondary Ab: Goat Anti-Mouse IgG H&L pAb (HRP Conjugate)
Exposure time: 60+ seconds
Predicted band size: Multiple
Observed band size: Multiple
IHC-P

Tissue: Mouse cerebrum
Section type: Formalin-fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:2000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-101.

Tissue: Human liver
Section type: Formalin-fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:2000
Primary Ab incubation: 1 hour at room temperature
Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to Use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-101.

Tissue: Human testis
Section type: Formalin-fixed & paraffin-embedded section
Retrieval method: High temperature and high pressure
Retrieval buffer: Tris/EDTA buffer, pH 9.0
Primary Ab dilution: 1:2000
Primary Ab incubation: 1 hour at room temperature
Secondary ab: Anti-Rabbit and Mouse Polymer HRP (Ready to use)
Counter stain: Hematoxylin (blue)
Description: The brown color represents the positive signal observed with PTM-101.

Research Use

For research use only, not for use in diagnostic procedures.

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  • NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis
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  • Confrontation with kidney inflammation through a HMGB1-targeted peptide augments anti-fibrosis therapy
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  • SIRT2-mediated deacetylation of glutathione transferase alleviates oxidative damage and increases the heat tolerance of Pleurotus ostreatus
    Year 2024
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    Authors Huihui Li, et al.
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  • The involvement of lysine glutarylation and mitochondria in spermatic movement deficiency induced by hexavalent chromium
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    Authors Yimin Cheng, et al.
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  • Effect of HDAC9-induced deacetylation of glycolysis-related GAPDH lysine 219 on rotavirus replication in rotavirus-infected Caco-2 cells
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    Authors Song Lijun, et al.
    Applications Unspecified
    Reactivity
  • Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis
    Year 2024
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    Authors Runhua Du, et al.
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  • Multi-omics analysis explores the impact of ofloxacin pressure on the metabolic state in Escherichia coli
    Year 2024
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    Authors Xiaoyu Yi, et al.
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  • Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD)
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    Journal MOLECULAR MEDICINE
    Authors Xie Bin, et al.
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  • Fisetin disrupts mitochondrial homeostasis via superoxide dismutase 2 acetylation in pancreatic adenocarcinoma
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    Authors Yimin Ding, et al.
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  • Preliminary study on the mechanism of SAHA in the treatment of refractory epilepsy induced by GABRG2(F343L) mutation
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    Authors Jie Wang, et al.
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    Authors Xiao-Yi Xiong, et al.
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  • NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
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    Authors Chen Hengxing, et al.
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    Reactivity
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    Authors Liu Yabo, et al.
    Applications Unspecified
    Reactivity
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    Applications Unspecified
    Reactivity
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    Year 2023
    Journal PLoS One
    Authors Erika Minami, et al.
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    Reactivity
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    Year 2023
    Journal SCIENCE OF THE TOTAL ENVIRONMENT
    Authors Xiaotong Wang, et al.
    Applications Unspecified
    Reactivity
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    Year 2023
    Journal Advanced Science
    Authors Qifan Hu, et al.
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    Reactivity
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    Year 2023
    Journal PLANT CELL
    Authors Huang Li, et al.
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    Reactivity
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    Authors Kou Fan, et al.
    Applications Unspecified
    Reactivity
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    Year 2023
    Journal Cell and Bioscience
    Authors Xu Xiaodong, et al.
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  • HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells
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    Authors Mi Shen, et al.
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    Year 2022
    Journal Scientific Reports
    Authors Li Bing, et al.
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  • Integrated insights into the mechanisms underlying sepsis-induced myocardial depression using a quantitative global proteomic analysis
    Year 2022
    Journal Journal of Proteomics
    Authors Ni Yang, et al.
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  • The Acyl-CoA Specificity of Human Lysine Acetyltransferase KAT2A
    Year 2022
    Journal BIOCHEMISTRY
    Authors Ananya Anmangandla, et al.
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  • Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle
    Year 2022
    Journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
    Authors Mingjuan Gu, et al.
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  • A Comprehensive Analysis of the Lysine Acetylome in the Aquatic Animals Pathogenic Bacterium Vibrio mimicus
    Year 2022
    Journal Frontiers in Microbiology
    Authors Wang Junlin, et al.
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  • Multi-omics analyses reveal the mechanisms of Arsenic-induced male reproductive toxicity in mice
    Year 2021
    Journal JOURNAL OF HAZARDOUS MATERIALS
    Authors Zijun Peng, et al.
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  • GCN5-mediated PKM2 acetylation participates in benzene-induced hematotoxicity through regulating glycolysis and inflammation via p-Stat3/IL17A axis
    Year 2021
    Journal ENVIRONMENTAL POLLUTION
    Authors Wei Zhang, et al.
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  • Global Profiling of 2-hydroxyisobutyrylome in Common Wheat
    Year 2021
    Journal GENOMICS PROTEOMICS & BIOINFORMATICS
    Authors Ning Zhang, et al.
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  • Poplar acetylome profiling reveals lysine acetylation dynamics in seasonal bud dormancy release
    Year 2021
    Journal PLANT CELL AND ENVIRONMENT
    Authors Xiaoli Liao, et al.
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  • Malonyl-proteome profiles of Staphylococcus aureus reveal lysine malonylation modification in enzymes involved in energy metabolism
    Year 2021
    Journal Proteome Science
    Authors Shi Yanan, et al.
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  • Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins
    Year 2020
    Journal NUCLEIC ACIDS RESEARCH
    Authors Ren Xiangle, et al.
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  • Identification of lysine isobutyrylation as a new histone modification mark
    Year 2020
    Journal NUCLEIC ACIDS RESEARCH
    Authors Zhu Zhesi, et al.
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  • The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer
    Year 2020
    Journal Theranostics
    Authors Hong Zhu, et al.
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  • Posttranslational lysine 2-hydroxyisobutyrylation of human sperm tail proteins affects motility
    Year 2020
    Journal HUMAN REPRODUCTION
    Authors Cheng Yi-min, et al.
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  • Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome
    Year 2020
    Journal Frontiers in Cell and Developmental Biology
    Authors Min Zheying, et al.
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  • Integrative Proteome and Acetylome Analyses of Murine Responses to Cryptococcus neoformans Infection
    Year 2020
    Journal Frontiers in Microbiology
    Authors Li Hailong, et al.
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  • Acetylation of BcHpt Lysine 161 Regulates Botrytis cinerea Sensitivity to Fungicides, Multistress Adaptation and Virulence
    Year 2020
    Journal Frontiers in Microbiology
    Authors Yang Qianqian, et al.
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  • Metabolic regulation of gene expression by histone lactylation
    Year 2019
    Journal NATURE
    Authors Zhang Di, et al.
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  • SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis
    Year 2019
    Journal Nature Metabolism
    Authors Liu Zuojun, et al.
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  • Fungal acetylome comparative analysis identifies an essential role of acetylation in human fungal pathogen virulence
    Year 2019
    Journal Communications Biology
    Authors Li Yanjian, et al.
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  • Lysine glutarylation in human sperm is associated with progressive motility
    Year 2019
    Journal HUMAN REPRODUCTION
    Authors Cheng Yi-min, et al.
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  • Lead-mediated inhibition of lysine acetylation and succinylation causes reproductive injury of the mouse testis during development
    Year 2019
    Journal TOXICOLOGY LETTERS
    Authors Qiangzhen Yang, et al.
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  • Dose-response regulation system for improving renal injury in diabetic nephropathy by buckwheat hull flavonoids
    Year 2019
    Journal Journal of Functional Foods
    Authors Yufang Tang, et al.
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  • p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis
    Year 2018
    Journal MOLECULAR CELL
    Authors He Huang, et al.
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  • Lysine benzoylation is a histone mark regulated by SIRT2
    Year 2018
    Journal Nature Communications
    Authors Huang He, et al.
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  • Protein Acylation is a General Regulatory Mechanism in Biosynthetic Pathway of Acyl-CoA-Derived Natural Products
    Year 2018
    Journal Cell Chemical Biology
    Authors Jun-Yu Xu, et al.
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  • Characterization of the Sperm Proteome and Reproductive Outcomes with in Vitro, Fertilization after a Reduction in Male Ejaculatory Abstinence Period *
    Year 2018
    Journal MOLECULAR & CELLULAR PROTEOMICS
    Authors Zi-Qi Shen, et al.
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  • Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first)
    Year 2018
    Journal JOURNAL OF BIOLOGICAL CHEMISTRY
    Authors Zhen Han, et al.
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  • Cadmium inhibits lysine acetylation and succinylation inducing testicular injury of mouse during development
    Year 2018
    Journal TOXICOLOGY LETTERS
    Authors Qiangzhen Yang, et al.
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  • Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway
    Year 2017
    Journal CELL RESEARCH
    Authors Huang He, et al.
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  • Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription
    Year 2017
    Journal CELL RESEARCH
    Authors Wei Wei, et al.
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  • MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300
    Year 2017
    Journal Cell Discovery
    Authors Liu Xiaoguang, et al.
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  • Systematic Analysis of Lysine Acetylation in the Halophilic Archaeon Haloferax mediterranei
    Year 2017
    Journal JOURNAL OF PROTEOME RESEARCH
    Authors Jingfang Liu, et al.
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  • Proteome-wide profiling of protein lysine acetylation in Aspergillus flavus
    Year 2017
    Journal PLoS One
    Authors Yangyong Lv, et al.
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  • Global Lysine Acetylome Analysis of Desiccated Somatic Embryos of Picea asperata
    Year 2016
    Journal Frontiers in Plant Science
    Authors Xia Yan, et al.
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  • Photo-lysine captures proteins that bind lysine post-translational modifications
    Year 2015
    Journal Nature Chemical Biology
    Authors Yang Tangpo, et al.
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  • Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark
    Year 2014
    Journal Nature Chemical Biology
    Authors Dai Lunzhi, et al.
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  • Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2
    Year 2014
    Journal JOURNAL OF NEUROSCIENCE
    Authors Cai Qi, et al.
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  • Lysine acetylproteome analysis suggests its roles in primary and secondary metabolism in Saccharopolyspora erythraea
    Year 2014
    Journal APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
    Authors Huang Dan, et al.
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